How Tomocube’s Holotomography and AI
Reveal the Secrets of Life Without Harming It.
Holotomography
Tomocube's leading-edge technology, Holotomography, is the next generation of 3D microscopic imaging technology which is utilized across various research fields.
In particular, holotomographic imaging allows for non-invasive, label-free observation of samples, enabling high-resolution data acquisition.
As such, it serves as an extremely powerful tool in life science research.
Products
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Tomocube HT-X1™ Plus
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Revolutionizing live-cell 3D imaging by integrating advanced holotomography with AI, pioneering new frontiers. HT-X1™ Plus stands out by delivering a faster, more automated, and highly efficient approach to live-cell imaging Holotomography. By integrating the advanced holotomography with multimodal capabilities, epifluorescence and spinning disk confocal (SDC) imaging optics. The HT-X1™ Plus enables non-invasive monitoring in live-cell 3D imaging for organoid and stem cell researchers to facilitate regenerative medicine, disease modeling, and drug discovery. The HT-X1™ Plus emphasizes automated quantification analysis, enhancing segmentation precision with AI models.
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TomoAnalysis™
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TomoAnalysis is a 3D image visualization and analysis software suite for analyzing Tomocube’s Holotomography data. Designed to analyze cellular and subcellular structures to produce quantified results, TomoAnalysis employs module-based data processing components, including AI-based analysis models, that can be flexibly combined to meet users' specific requirements for image analysis. The software takes advantage of its accurate quantification results to generate more precise and intuitive 3D visualization of the biological samples.
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Holotomography (HT) is a game-changer in the field of live cell imaging. HT allows for non-invasive observation of specimens in their native state, capturing high-resolution morphological details and dynamic cellular events at the subcellular level. Its 3D imaging capability combining quantitative analysis provides valuable insights into numerous phenomena such as cytotoxicity, cell-to-cell interaction, and organelle dynamics. This is the key to advancing applications in precision medicine and drug discovery.
HT stands out as the optimal solution for examining phenotypic details in stem cells, primary cells, or patient-derived samples, particularly when faced with challenges related to cell quantity and labeling. The innovative label-free analysis technology of HT opens up remarkable opportunities in cell therapy, tissue engineering, etc.
The HT system facilitates a deeper understanding of complex 3D cultured cells and tissue sections, such as organoids, spheroids, and microfluidic devices, including organ-on-a-chip. HT enables label-free, high-resolution, real-time visualization of 3D live specimens, preserving their natural state.
HT offers a unique advantage by facilitating longitudinal studies of live organoids and capturing dynamic cellular processes that were previously unobservable through conventional methods.
HT presents a revolutionary approach by enabling real-time, label-free observation of immune cell phenotypes and their behavior in three dimensions. The images tell the differences between cell states such as active or inactive T cells. HT provides invaluable insights into processes such as immune cell recognition and the immuno therapies.
HT facilitates label-free observation of protein condensates, such as those involved in liquid-liquid phase separation (LLPS). It provides real-time 3D visualization and quantitative analysis of protein concentrations using refractive index measurement. This capability enhances our understanding of protein dynamics and interactions within the cellular environment.
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Discover amazing life phenomena using Tomocube’s Holotomography imaging system in our collection of scientific publications.
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Explore Tomocube's wide range of application notes to find the right application for your research.
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Explore a fascinating library of high-resolution, label-free Holotomography cells from a variety of biological samples.